Reinhard Büttner, MD

Chief Scientific Officer & Co-Founder. Targos, Germany

Prof. Dr. med. Reinhard Buttner

Prof. Dr. med. Reinhard Büttner is Professor and Chairman- Institute for Pathology; University Hospital Cologne and Co-founder/Chief Scientific Officer, Targos Germany. He is a member of the German Academy for Sciences; Academia Moguntia and the The North Rhine-Westphalian Academy of Sciences in Düsseldorf, Germany.

Previously, he was Dean of the Medical Faculty and a Professor and Chairman for Pathology, University of Bonn. He holds an MD degree from the University of Mainz-Germany following residencies at Rheinisch-Westfälische Technische Hochschule Aachen; University of Regensburg (Germany) and post-doctoral work at the Gene Center Munich and MD Anderson Cancer Center, USA.

Prof. Büttner has published more than 450 peer-reviewed scientific papers in high-impact journals. Some representative publications since 2010 are:

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Metzger E, et al., Nature. 2010 Apr 1;464(7289):792-6

Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Weiss J, et al., Sci Transl Med. 2010 Dec 15;2(62):62ra93

FHL2 expression in peritumoural fibroblasts correlates with lymphatic metastasis in sporadic but not in HNPCC-associated colon cancer. Gullotti L et al., Lab Invest. 2011 Dec;91(12):1695-705

High nuclear poly(adenosine diphosphate-ribose) polymerase expression is predictive for BRCA1- and BRCA2-deficient breast cancer. Ozretić L, et al., J Clin Oncol. 2011 Dec 1;29(34):4586-8

A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation. Kamieniarz K, et al., Genes Dev. 2012 Apr 15;26(8):797-802

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor. Willmann D, et al., Int J Cancer. 2012 Dec 1;131(11):2704-9.

Hepatocarcinogenesis in non-cirrhotic liver is associated with a reduced number of clonal hepatocellular patches in non-tumorous liver parenchyma. Adam AC, et al., J Pathol. 2012 Nov;228(3):333-40.

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Peifer M, et al., Nat Genet. 2012 Oct;44(10):1104-10

Targeted Expression of Mutated ALK Induces Neuroblastoma in Transgenic Mice. Heukamp LC, et al., Sci Transl Med. 2012 Jul 4;4(141)

He is a recipient of many grants from German Research Foundation (DFG) and is a Board member and / or consultant to a number of private and public corporations.