Reinhard Büttner, MD

Chief Scientific Officer & Co-Founder. Targos, Germany

Prof. Dr. med. Reinhard Buttner

Prof. Dr. med. Reinhard Büttner is Professor and Chairman- Institute for Pathology; University Hospital Cologne and Co-founder/Chief Scientific Officer, Targos Germany. He is a member of the German Academy for Sciences; Academia Moguntia and the The North Rhine-Westphalian Academy of Sciences in Düsseldorf, Germany.

Previously, he was Dean of the Medical Faculty and a Professor and Chairman for Pathology, University of Bonn. He holds an MD degree from the University of Mainz-Germany following residencies at Rheinisch-Westfälische Technische Hochschule Aachen; University of Regensburg (Germany) and post-doctoral work at the Gene Center Munich and MD Anderson Cancer Center, USA.

Prof. Büttner has published more than 450 peer-reviewed scientific papers in high-impact journals. Some representative publications since 2010 are:

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Metzger E, et al., Nature. 2010 Apr 1;464(7289):792-6

Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Weiss J, et al., Sci Transl Med. 2010 Dec 15;2(62):62ra93

High nuclear poly(adenosine diphosphate-ribose) polymerase expression is predictive for BRCA1- and BRCA2-deficient breast cancer. Ozretić L, et al., J Clin Oncol. 2011 Dec 1;29(34):4586-8

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Peifer M, et al., Nat Genet. 2012 Oct;44(10):1104-10

Implementation of Amplicon Parallel Sequencing Leads to Improvement of Diagnosis and Therapy of Lung Cancer Patients. König K,et al J Thorac Oncol. 2015 Jul;10(7):1049-57.

Advance of theragnosis biomarkers in lung cancer: from clinical to molecular pathology and biology. Alidousty C, et al J Thorac Dis. 2019 Jan;11(Suppl 1):S3-S8.

He is a recipient of many grants from German Research Foundation (DFG) and is a Board member and / or consultant to a number of private and public corporations.