The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.

Reference: http://www.ncbi.nlm.nih.gov/gene/4233

Assay type: Immunohistochemistry (IHC)
What is analyzed: Semi-quantitative detection of human hepatocyte growth factor receptor protein (C-Met)
Platform: VENTANA BenchMark ULTRA
Kit/antibody: Clone SP44 (VENTANA)
Tissue Type: Gastric carcinoma
Required material: FFPE tissue

Assay type: bdISH (bright field dual in situ hybridization)
What is analyzed: c-MET Gene Amplification Status
Platform: INFORM MET DNA probe assay on VENTANA Benchmark XT
Tissue Type: Solid tumor tissue
Required material: FFPE tissue