c-Myc

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

Reference: http://www.ncbi.nlm.nih.gov/gene/4609

Assay type: Fluorescence in situ hybridization (FISH)
What is analyzed: Copy number of  the human oncogenic transcription factor c-Myc
Platform: Hybridizer (Dako)
Kit/Probe: Histology FISH Accessory Kit Dako
Tissue Type: Breast carcinoma
Required material: FFPE tissue