The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.


Assay type: Immunohistochemistry (IHC)
What is analyzed: Semi-quantitative detection of human Cyclin D1 protein
Platform: VENTANA BenchMark® XT
Kit/antibody: Clone SP4, DCS Diagnostik Systeme Hamburg, #CI677C01
Tissue Type: Various solid tumours
Required material: FFPE material