ER/PR

Estrogen and its receptors (ER) are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

Reference: http://www.ncbi.nlm.nih.gov/gene/2099

Progesterone receptor mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap.

Reference: http://www.ncbi.nlm.nih.gov/gene/5241

Assay type: Immunohistochemistry (IHC)
What is analyzed: Semi-quantitative detection of Estrogen/ progesterone receptor protein
Platform: ER/PR pharmDX™ Kit on DAKO Autostainer Plus
Tissue Type: Breast carcinoma tissue (primary or metastatic tumor)
Required material: FFPE tissue