The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.


Assay type: Immunohistochemistry (IHC)
What is analyzed: Phosphorylation status of human Glycoprotein 130 (also known IL6ST, IL6-beta or CD130)
Platform: VENTANA BenchMark® XT
Kit/antibody: Rabbit polyclonal to CD130 (abcam ab59389)
Reference: Radtke, et al 2010, J Cell Sci 123, 947-959.
Tissue Type: Skin
Required material: FFPE tissue