This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

Reference: http://www.ncbi.nlm.nih.gov/gene/3480

Assay type: Immunohistochemistry (IHC)
What is analyzed: Semi-quantitative detection of  human IGF-1 receptor protein
Platform: VENTANA BenchMark® XT
Kit/antibody: Clone G11, Ventana, #790-4346
Tissue Type: Breast carcinoma, Gastric carcinoma
Required material: FFPE tissue