The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb detects endogenous levels of p44 and p42 MAP Kinase (Erk1 and Erk2) when dually phosphorylated at Thr202 and Tyr204 of Erk1 (Thr185 and Tyr187 of Erk2), and singly phosphorylated at Thr202.

Reference: http://www.ncbi.nlm.nih.gov/gene/5594

Assay type: Immunohistochemistry (IHC)
What is analyzed: Semi-quantitative detection of  human phosphorylated MAP kinase p44/p42
Platform: Manual assay
Kit/antibody: Clon 2OG11, Cell Signaling Technology®, #4376
Tissue Type: Various solid tumours
Required material: FFPE tissue