pEGFR

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Anti-phospho Y1068-EGR receptor antibody detects human phosphorylated epidermal growth factor receptor 1 (EGFR) protein.

Referencehttp://www.ncbi.nlm.nih.gov/gene/1956

Assay type: Immunohistochemistry (IHC)
What is analyzed: Semi-quantitative detection of  human phosphorylated epidermal growth factor receptor 1 (EGFR) protein
Platform: Manual assay
Kit/antibody: anti-phospho Y1068-EGR receptor, Clone D7A5, Cell Signaling Technologies®, #3777
Tissue Type: Breast carcinoma
Required material: FFPE tissue